Research Express

10.1038/s41421-024-00683-y  

Single-cell sequencing depicts tumor architecture and empowers clinical decision in metastatic conjunctival melanoma

Hanhan Shi#, Hao Tian#, Tianyu Zhu#, Qili Liao#, Chang Liu, Peng Yuan, Yongyun Li, Jie Yang, Chunyan Zong, Shichong Jia, Jing Ruan, Shengfang Ge, Renbing Jia*, Peiwei Chai*, Shiqiong Xu*, Xianqun Fan*

10.1002/advs.202403107  

A Novel Nanozyme to Enhance Radiotherapy Effects by Lactic Acid Scavenging, ROS Generation, and Hypoxia Mitigation

Yiran Yao#, Ru Xu#, Weihuan Shao#, Ji Tan, Shaoyun Wang, Shuhan Chen, Ai Zhuang*, Xuanyong Liu*, Renbing Jia*

10.1016/j.apsb.2023.12.002  

EHMT2 promotes tumorigenesis in GNAQ/11-mutant uveal melanoma via ARHGAP29-mediated RhoA pathway

Yongyun Li#, Tianyu Zhu#, Jie Yang#, Qianqian Zhang, Shiqiong Xu, Shengfang Ge, Renbing Jia*, Jianming Zhang*, Xianqun Fan*

10.1093/nar/gkad1193  

Histone lactylation-boosted ALKBH3 potentiates tumor progression and diminished promyelocytic leukemia protein nuclear condensates by m1A demethylation of SP100A

Xiang Gu#, Ai Zhuang#, Jie Yu#, Ludi Yang#, Shengfang Ge, Jing Ruan, Renbing Jia*, Xianqun Fan*, Peiwei Chai*

10.1002/cac2.12471  

Targeting histone deacetylase suppresses tumor growth through eliciting METTL14-modified m6A RNA methylation in ocular melanoma

Ai Zhuang#, Xiang Gu#, Tongxin Ge#, Shaoyun Wang, Shengfang Ge, Peiwei Chai*, Renbing Jia*, Xianqun Fan*

10.1016/S2352-4642(23)00141-4  

Intravenous versus super-selected intra-arterial chemotherapy in children with advanced unilateral retinoblastoma: an open-label, multicentre, randomised trial

Xuyang Wen#, Jiayan Fan#, Mei Jin#, Hua Jiang#, Jiakai Li#, Minglei Han#, Chengyue Zhang, Xiaoyu He, Yingxiu Luo, Jie Yang, Min Zhou, Jia Tan*, Xinji Yang*, Xunda Ji*, Jing Zhang*, Junyang Zhao*, Renbing Jia*, Xianqun Fan*

10.1038/s41421-023-00521-7  

Nuclear PD-L1 promotes EGR1-mediated angiogenesis and accelerates tumorigenesis

Jie Yu#, Ai Zhuang#, Xiang Gu#, Yu Hua, Ludi Yang, Shengfang Ge, Jing Ruan, Peiwei Chai*, Renbing Jia*, Xianqun Fan*

10.1016/j.ophtha.2022.02.029  

American Joint Committee on Cancer (AJCC) tumor staging system predicts the outcome and metastasis pattern in conjunctival melanoma

Shichong Jia#, Tianyu Zhu#, Hanhan Shi#, Chunyan Zong#, Yongyang Bao, Xuyang Wen, Shengfang Ge, Jing Ruan, Shiqiong Xu*, Renbing Jia*

10.1002/smtd.202101220  

Monitoring Retinoblastoma by Machine Learning of Aqueous Humor Metabolic Fingerprintin

Wanshan Liu#, Yingxiu Luo#, Jingjing Dai#, Ludi Yang, Lin Huang, Ruimin Wang, Wei Chen, Yida Huang, Shiyu Sun, Jing Cao, Jiao Wu, Minglei Han, Jiayan Fan, Mengjia He, Kun Qian*, Xianqun Fan*, Renbing Jia*

10.1016/j.ophtha.2021.09.002  

Eye-preserving therapies for advanced retinoblastoma: a multicenter cohort of 1678 patients in China

Chuandi Zhou#, Xuyang Wen#, Yi Ding#, Jingwen Ding, Mei Jin, Zhenyin Liu, Sha Wang, Minglei Han, Hongfeng Yuan, Yishuang Xiao, Li Wu, Jiancang Wang, Yangjun Li, Jiawei Yu, Yuechun Wen, Juan Ye, Rong Liu, Zhijun Chen, Shangcai Xue, Wei Lu, Hongfei Liao, Jizhe Cui, Dan Zhu, Lu Fang, Song Tang, Yu Wu, Tseden Yangkyi, Guanghong Zhang, Miershalijiang Wubuli, Huiyu Guo, Xian Wang, Yanjin He, Xunlun Sheng, Qing Wang, Yingxiu Luo, Jiayan Fan, Jinlei Qi, Zhangsheng Yu, Jia Tan, Jianhong Liang, Xiantao Sun, Liwen Jin, Xinji Yang, Jing Zhang*, Xunda Ji*, Junyang Zhao*, Renbing Jia*, Xianqun Fan*

10.1002/smtd.202100848  

Nanoprotection Against Retinal Pigment Epithelium Degeneration via Ferroptosis Inhibition

Zhimin Tang#, Minfeng Huo#, Yahan Ju#, Xiaochan Dai, Ni Ni, Yan Liu, Huiqin Gao, Dandan Zhang, Hao Sun, Xianqun Fan*, Yu Chen*, Ping Gu*.

10.1016/j.preteyeres.2021.101030  

Regulation of epigenetic homeostasis in uveal melanoma and retinoblastoma

Peiwei Chai#, Ruobing Jia#, Yongyun Li#, Chuandi Zhou#, Xiang Gu, Ludi Yang, Hanhan Shi, Hao Tian, Huimin Lin, Jie Yu, Ai Zhuang, Shengfang Ge, Renbing Jia, Xianqun Fan*.

10.1016/j.ajo.2021.09.026  

Contemporary update of retinoblastoma in China: Three-decade changes in epidemiology, clinical features, treatments and outcomes

YingxiuLuoMD#, ChuandiZhouMD, PhD, FanglinHeMD, JiayanFanMD, PhD, XuyangWenMD, PhD, YiDingMD, PhD, YanpingHanMD, JingwenDingMD, MeiJinMD, ZhenyinLiuMD, ShaWangMD, MingleiHanMD, HongfengYuanMD, HongSunMD, YishuangXiaoMD, LiWuMD, JiancangWangMD, YangjunLiMD, HuashengYangMD, PhD, JiaweiYuMD, PhD, JianyangGong, YuxinXu, YuechunWen, ZiqingGaoMD, LixinMeiMD, JuanYeMD, HuLiuMD, ZhijunChenMD, ShangcaiXueMD, RongLiuMD, HongChenMD, WeiLuMD, HongfeiLiaoMD, QingGuoMD, JizheCuiMD, DanZhuMD, FangLuMD, SongTangMD, YuWuMD, TsedenYangkyiMD, ZhangGuanghongMD, MiershalijiangWubuliMD, GuohuiyuMD, XianWangMD, YanjinHeMD, XunlunShengMD, QingWangMD, JiaTanMD, PhD, JianhongLiangMD, PhD10XiantaoSunMD, PhD, JingZhangMD, PhD, XundaJiMD, PhD, LiwenJinMD, PhD, JunyangZhaoMD, PhD, XinjiYangMD, PhD, RenbingJiaMD, PhD, XianqunFanMD, PhD*.

10.1136/bjophthalmol-2021-319789   

Intraepithelial growth pattern for eyelid sebaceous carcinoma: a cohort of 214 patients from a single institution

Chuandi Zhou#, Peiwei Chai# , Wenwen Xia, Jiang Li*, Renbing Jia*, Xianqun Fan*.

10.1016/j.ophtha.2021.09.002.  

Eye-Preserving Therapies for Advanced Retinoblastoma: A Multicenter Cohort of 1678 Patients in China

Chuandi Zhou #, Xuyang Wen #, Yi Ding #, Jingwen Ding  , Mei Jin, Zhenyin Liu, Sha Wang, Minglei Han, Hongfeng Yuan, Yishuang Xiao, Li Wu, Jiancang Wang, Yangjun Li, Jiawei Yu, Yuechun Wen, Juan Ye, Rong Liu, Zhijun Chen, Shangcai Xue, Wei Lu, Hongfei Liao, Jizhe Cui, Dan Zhu, Fang Lu, Song Tang, Yu Wu, Tseden Yangkyi, Guanghong Zhang, Miershalijiang Wubuli, Huiyu Guo, Xian Wang, Yanjin He, Xunlun Sheng, Qing Wang, Yingxiu Luo, Jiayan Fan, Jinlei Qi, Zhangsheng Yu, Jia Tan, Jianhong Liang, Xiantao Sun, Liwen Jin, Xinji Yang, Jing Zhang *, Xunda Ji *, Junyang Zhao *, Renbing Jia *, Xianqun Fan*.

10.1002/advs.202002404  

Dose-Dependent Carbon-Dot-Induced ROS Promote Uveal Melanoma Cell Tumorigenicity via Activation of mTOR Signaling and Glutamine Metabolism

Yi Ding#,  Jie Yu#, Xingyu Chen,  Shaoyun Wang,  Zhaoxu Tu,  Guangxia Shen,  Huixue Wang,  Renbing Jia,  Shengfang Ge,  Jing Ruan*, Kam W. Leong*,  and Xianqun Fan *.

10.3389/fmed.2021.658305.  

Comparison of Intra-Arterial Chemotherapy Efficacy Delivered Through the Ophthalmic Artery or External Carotid Artery in a Cohort of Retinoblastoma Patients

Shichong Jia #, Xuyang Wen #, Min Zhou #, Xiaoyu He , Minglei Han , Jiayan Fan *, Renbing Jia *, Xianqun Fan *.

10.1136/bjophthalmol-2021-319118  

Risk factors for ophthalmic artery stenosis and occlusion in patients with retinoblastoma treated with intra-arterial chemotherapy

Min Zhou # , Xuyang Wen #, Shichong Jia #, Yanping Han , Xiaoyu He , Minglei Han , Wei Xu , Jiayan Fan *, Renbing Jia *, Xianqun Fan *.

Genome Biol 2021. doi:  10.1186/s13059-021-02308-z  

Histone lactylation drives oncogenesis by facilitating m6A reader protein YTHDF2 expression in ocular melanoma.

Yu Jie, Chai Peiwei, Xie Minyue, Ge Shengfang, Ruan Jing, Xianqun Fan, Renbing Jia.

Adv Sci (Weinh) 2021 Apr; 8(8): 2002404. doi: 10.1002/advs.202002404

Dose-Dependent Carbon-Dot-Induced ROS Promote Uveal Melanoma Cell Tumorigenicity via Activation of mTOR Signaling and Glutamine Metabolism.

Ding Y, Yu J, Chen X, Wang S, Tu Z, Shen G, Wang H, Jia R, Ge S, Ruan J, Leong KW, Fan X. 

Bioact Mater. 2020 Dec 26;6(7):1973-1987. doi: 10.1016/j.bioactmat.2020.12.010. PMID: 33426371

The application of nanoparticles in cancer immunotherapy: Targeting tumor microenvironment. 

Yang M, Li J, Gu P, Fan X. 

Advanced Materials 2020 Nov 27;e2005096. doi: 10.1002/adma.202005096

Imaging cellular aerobic glycolysis using carbon dots for early warning of tumorigenesis.  

Li J, Yang S, Liu Z, Wang G, He P, Wei W, Yang M, Deng Y, Gu P, Xie X, Kang Z, Ding G, Zhou H, Fan X.

Science Advances. 2020; 6 : eabc5022

CRISPR-mediated BMP9 Ablation Promotes Liver Steatosis via the Downregulation of PPARα Expression.

Z. Yang, P. Li, Q. Shang, Y. Wang, J. He, S. Ge, R. Jia, Fan X.

Nucleic Acids Research 2020 DOI: 10.1093/nar PMID: 33196849

Generation of onco-enhancer enhances chromosomal remodeling and accelerates tumorigenesis.

Chai P, Yu J, Jia R, Wen X, Ding T, Zhang X, Ni H, Jia R, Ge S, Zhang H, Fan X.

Cell Death Differ. 2020 Aug 19. doi: 10.1038/s41418-020-0600-6

CircRNA-vgll3 promotes osteogenic differentiation of adipose-derived mesenchymal stem cells via modulating miRNA-dependent integrin α5 expression.

Zhang D, Ni N, Wang Y, Tang Z, Gao H, Ju Y, Sun N, He X, Gu P, Fan X.

Nat Rev Dis Primers, 2020,6:24

Uveal melanoma.

Martine J.Jager, Carol L.Shields, Colleen M.Cebulla, Mohamed H.Abdel-Rahman, Hans E.Grossniklaus, Marc-Henri.Stern, Richard D.Carvajal, Rubens N.Belfort, Renbing Jia, Jerry A.Shields, Bertil E.Damato.

Chemical Engineering Journal. 395, 1 September 2020, 125098

Integrating eggshell-derived CaCO3 /MgO nanocomposites and chitosan into a biomimetic scaffold for bone regeneration.

Ya-zhuo Huang , Yong-rong Ji , Ze-wen Kang , Fang Li , Sheng-fang Ge ,Da-Peng Yang,  Jing Ruan , Fan X.

J Hematol Oncol 2020. doi: 10.1186/s13045-020-00883-5

Genetic alteration, RNA expression, and DNA methylation profiling of coronavirus disease 2019 (COVID-19) receptor ACE2 in malignancies: a pan-cancer analysis.

Chai P, Yu J, Ge S, Jia R, Fan X.

Mol Cancer 2020. doi: 10.1186/s12943-020-01232-3

A novel LncRNA transcript, RBAT1, accelerates tumorigenesis through interacting with HNRNPL and cis-activating E2F3.

Xiaoyu He, Peiwei Chai, Fang Li, Leilei Zhang, Chuandi Zhou, Xiaoling Yuan, Yongyun Li, Jie Yang, Yingxiu Luo, Shengfang Ge, He Zhang, Renbing Jia, Xianqun Fan.

Mol Cancer. 2020 Apr 17;19(1):78. Review

Novel insight into the regulatory roles of diverse RNA modifications: Re-defining the bridge between transcription and translation. 

Shi H, Chai P, Jia R, Fan X.

Mol Cancer. 2019 Jan 9;18(1):6

The novel roles of circRNAs in human cancer.

Shang Q, Yang Z, Jia R, Ge S.

Autophagy. 2020 Jul;16(7):1186-1199

ZNNT1 long noncoding RNA induces autophagy to inhibit tumorigenesis of uveal melanoma by regulating key autophagy gene expression.

Li P, He J, Yang Z, Ge S, Zhang H, Zhong Q, Fan X.

Mol Cancer. 2019 Nov 14;18(1):161

m6A modification suppresses ocular melanoma through modulating HINT2 mRNA translation. 

Jia R, Chai P, Wang S, Sun B, Xu Y, Yang Y, Ge S, Jia R, Yang YG, Fan X.

Adv. Funct. Mater., 2018, 28(30), 1800881

Emancipating target-functionalized carbon dots from autophagy vesicles for a novel visualized tumour therapy. 

Li J, Yang S, Deng Y, Chai P, Yang Y, He X, Xie X, Kang Z, Ding G, Zhou H, Fan X.

Nucleic Acids Res. 2018 Jul 6;46(12):6041-6056

Dynamic chromosomal tuning of a novel GAU1 lncing driver at chr12p13.32 accelerates tumorigenesis. 

Chai P, Jia R, Jia R, Pan H, Wang S, Ni H, Wang H, Zhou C, Shi Y, Ge S, Zhang H, Fan X.

Mol Cancer. 2017 Nov 17;16(1):173

Novel insights into chromosomal conformations in cancer.

Jia R, Chai P, Zhang H, Fan X.

Adv Funct Mater. 2016, 26, 1085–1097

Enhanced Physiochemical and Mechanical Performance of Chitosan-Grafted Graphene Oxide for Superior Osteoinductivity.

Ruan J, Wang X, Yu Z, Wang Z, Xie Q, Zhang D, Huang Y, Zhou H, Bi X, Xiao C, Gu P* and Fan X.

Cancer Cell. 2017 Aug 14;32(2):204-220.e15. doi: 10.1016/j.ccell.2017.07.003. Erratum in: Cancer Cell. 2018 Jan 8;33(1):151

Integrative Analysis Identifies Four Molecular and Clinical Subsets in Uveal Melanoma.

Robertson AG, Shih J, Yau C, Gibb EA, Oba J, Mungall KL, Hess JM, Uzunangelov V, Walter V, Danilova L, Lichtenberg TM, Kucherlapati M, Kimes PK, Tang M, Penson A, Babur O, Akbani R, Bristow CA, Hoadley KA, Iype L, Chang MT; TCGA Research Network, Cherniack AD, Benz C, Mills GB, Verhaak RGW, Griewank KG, Felau I, Zenklusen JC, Gershenwald JE, Schoenfield L, Lazar AJ, Abdel-Rahman MH, Roman-Roman S, Stern MH, Cebulla CM, Williams MD, Jager MJ, Coupland SE, Esmaeli B, Kandoth C, Woodman SE.

JAMA Oncol. 2020 May 1;6(5):685-695. doi: 10.1001/jamaoncol.2019.6716. Erratum in: JAMA Oncol. 2020 Nov 1;6(11):1815

Global Retinoblastoma Presentation and Analysis by National Income Level.

Global Retinoblastoma Study Group, Fabian ID, Abdallah E, Abdullahi SU, Abdulqader RA, Adamou Boubacar S, Ademola-Popoola DS, Adio A, Afshar AR, Aggarwal P, Aghaji AE, Ahmad A, Akib MNR, Al Harby L, Al Ani MH, Alakbarova A, Portabella SA, Al-Badri SAF, Alcasabas APA, Al-Dahmash SA, Alejos A, Alemany-Rubio E, Alfa Bio AI, Alfonso Carreras Y, Al-Haddad C, Al-Hussaini HHY, Ali AM, Alia DB, Al-Jadiry MF, Al-Jumaily U, Alkatan HM, All-Eriksson C, Al-Mafrachi AARM, Almeida AA, Alsawidi KM, Al-Shaheen AASM, Al-Shammary EH, Amiruddin PO, Antonino R, Astbury NJ, Atalay HT, Atchaneeyasakul LO, Atsiaya R, Attaseth T, Aung TH, Ayala S, Baizakova B, Balaguer J, Balayeva R, Balwierz W, Barranco H, Bascaran C, Beck Popovic M, Benavides R, Benmiloud S, Bennani Guebessi N, Berete RC, Berry JL, Bhaduri A, Bhat S, Biddulph SJ, Biewald EM, Bobrova N, Boehme M, Boldt HC, Bonanomi MTBC, Bornfeld N, Bouda GC, Bouguila H, Boumedane A, Brennan RC, Brichard BG, Buaboonnam J, Calderón-Sotelo P, Calle Jara DA, 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Ophthalmology. 2020 May;127(5):699-703. doi: 10.1016/j.ophtha.2019.11.015. Epub 2019 Nov 26. Erratum in: Ophthalmology. 2020 Aug;127(8):1131. PMID: 31980249

Upper Cranial Nerve Involvement and Immunoglobulin G4-Related Optic Neuropathy.

Lai KKH, Chan RYC, Chin JKY, Li KKW, Young AL, Yuen HKL, Ko STC, Chong KKL.

Eye (Lond). 2019 Jan;33(1):87-96. doi: 10.1038/s41433-018-0244-7. Epub 2018 Nov 1

Retinoblastoma in Asia.

Jain M, Rojanaporn D, Chawla B, Sundar G, Gopal L, Khetan V.

Graefes Arch Clin Exp Ophthalmol. 2020 Feb;258(2):403-410. doi: 10.1007/s00417-019-04515-8

Characteristics of lacrimal passage diseases by 80-MHz ultrasound biomicroscopy: an observational study.

Yan X, Xiang N, Hu W, Liu R, Luo B.

Indian J Ophthalmol. 2019 Jun;67(6):763-771. doi: 10.4103/ijo.IJO_841_19

Coats disease: An overview of classification, management and outcomes.

Sen M, Shields CL, Honavar SG, Shields JA.

Orbital Lymphoma-An International Multicenter Retrospective Study. Am J Ophthalmol. 2019 Mar;199:44-57. doi: 10.1016/j.ajo.2018.11.002

Orbital Lymphoma-An International Multicenter Retrospective Study.

Olsen TG, Holm F, Mikkelsen LH, Rasmussen PK, Coupland SE, Esmaeli B, Finger PT, Graue GF, Grossniklaus HE, Honavar SG, Khong JJ, McKelvie PA, Mulay K, Sjö LD, Vemuganti GK, Thuro BA, Heegaard S.

Eur J Ophthalmol. 2021 Jul 31:11206721211035613. doi: 10.1177/11206721211035613

Correction of lower eyelid retraction combined with entropion in thyroid eye disease patients of East Asian ancestry.

Ma Y, Tang M, Kikkawa DO, Lu W.

Clin Exp Ophthalmol. 2020 Jul;48(5):554-557. doi: 10.1111/ceo.13805 

Uveal melanoma in 2020: Does size still matter?

Lim LS, Giblin ME.

PLoS One. 2020 Aug 6;15(8):e0237015. doi: 10.1371/journal.pone.0237015

Protein tyrosine phosphatase 1B as a therapeutic target for Graves' orbitopathy in an in vitro model.

Byeon HJ, Kim JY, Ko J, Lee EJ, Don K, Yoon JS.

Exp Eye Res. 2020 Oct;199:108184. doi: 10.1016/j.exer.2020.108184

Serum exosomal miRNA as biomarkers for Retinoblastoma.

Ravishankar H, Mangani AS, Phoebe Moses GL, Mani SP, Parameswaran S, Khetan V, Ganesan S, Krishnakumar S.

Indian J Ophthalmol. 2020 Jul;68(7):1281-1291. doi: 10.4103/ijo.IJO_1669_20

Ocular oncology practice guidelines during COVID-19 pandemic-An expert consensus.

Manjandavida FP, Honavar SG, Kim U, Singh U, Menon V, Das S, Kaliki S, Palanivelu MS, Khetan V, Shah PK, Rishi P, Mulay K, Gandhi A, Vadhiraja BM, Reddy VA, Bhat S, Rao V.

Int J Surg Pathol. 2021 Jun;29(4):406-407. doi: 10.1177/1066896920925168

Primary Well-Differentiated Liposarcoma of the Orbit.

Lam TC, Yuen HKL, Cheuk W.

Indian J Ophthalmol. 2019 Dec;67(12):2048-2049. doi: 10.4103/ijo.IJO_1271_19

Iridocilary tuberculoma mimicking melanoma.

Latiff N, Sudharshan S, Verma A, Khetan V, Biswas J.

Int J Surg Pathol. 2020 Dec;28(8):888-892. doi: 10.1177/1066896920917445

Ocular Sebaceous Carcinoma In Situ With Biphenotypic Differentiation: A Reappraisal of the Alternative Origin of the Tumor.

Yim CL, Lam SC, Yuen HKL, Cheuk W.